Caddisfly Inspired Phosphorylated Poly(ester urea)-Based Degradable Bone Adhesives

被引：46

作者：

Bhagat, Vrushali ^{[1
]}

O'Brien, Emily ^{[1
]}

Zhou, Jinjun ^{[1
,2
]}

Becker, Matthew L. ^{[1
]}

机构：

[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA

[2] State Key Lab High Performance Civil Engn Mat, Nanjing 211103, Jiangsu, Peoples R China

来源：

BIOMACROMOLECULES | 2016年 / 17卷 / 09期

基金：

美国国家科学基金会;

关键词：

UNDERWATER ADHESIVES; SILK; POLYMERS; SURFACES; MONOMERS;

D O I：

10.1021/acs.biomac.6b00875

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bone and tissue adhesives are essential in surgeries for wound healing, hemostasis, tissue reconstruction, and drug delivery. However, there are very few degradable materials with high adhesion strengths that degrade into bioresorbable byproducts. Caddisfly adhesive silk is interesting due to the presence of phosphoserines, which are thought to afford adhesive properties. In this work, phosphoserine-valine poly(ester urea) copolymers with 2% and 5% phosphoserine content were synthesized to mimic caddisfly adhesive silk. Significantly, the materials are ethanol soluble and water insoluble, making them clinically relevant. Their physical properties were quantified, and the adhesion properties were studied on aluminum and bovine bone substrates before and after cross-linking with Ca2+ ions. The adhesive strength of the phosphorylated copolymer on a bone substrate after cross-linking with Ca2+ was 439 +/- 203 kPa, comparable to commercially available PMMA. bone cement (530 +/- 133 kPa).

引用

页码：3016 / 3024

页数：9

共 31 条

[1]

Viscoelastic and biological performance of low-modulus, reactive calcium phosphate-filled, degradable, polymeric bone adhesives [J].