In Vivo Osseointegration of Nano-Designed Composite Coatings on Titanium Implants

被引：81

作者：

Facca, Sybille ^{[1
,2
,3
,4
]}

Lahiri, Debrupa ^{[2
,3
]}

Fioretti, Florence ^{[1
,5
]}

Messadeq, Nadia ^{[6
]}

Mainard, Didier ^{[7
,8
]}

Benkirane-Jessel, Nadia ^{[1
,7
,8
]}

Agarwal, Arvind ^{[2
,3
]}

机构：

[1] INSERM, Inst Natl Sante & Rech Med, Fac Med, U977, F-67085 Strasbourg, France

[2] Florida Int Univ, Dept Mech & Mat Engn, Plasma Forming Lab, Miami, FL 33174 USA

[3] Florida Int Univ, Dept Mech & Mat Engn, Nanomech & Nanotribol Lab, Miami, FL 33174 USA

[4] Strasbourg Univ Hosp, Dept Hand Surg, F-67403 Illkirch Graffenstaden, France

[5] Univ Strasbourg, Fac Chirurg Dent, Strasbourg, France

[6] IGBMC, Illkirch Graffenstaden, France

[7] Univ Nancy 1, CNRS, UMR 7561, F-54000 Nancy, France

[8] Univ Nancy 1, Hop Cent, Ctr Ortopedie Nancy, F-54000 Nancy, France

来源：

ACS NANO | 2011年 / 5卷 / 06期

基金：

美国国家科学基金会;

关键词：

hydroxyapatite; carbon nanotubes; osseointegration; bone induction in vivo; elastic modulus; titanium implants; WALLED CARBON NANOTUBES; MECHANICAL-PROPERTIES; APATITE FORMATION; TOXICITY; VITRO; DIFFERENTIATION; BEHAVIOR; CELLS;

D O I：

10.1021/nn200768c

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

This is the first in vivo study of plasma-sprayed carbon nanotube (CNT)-reinforced hydroxyapatite (HA) coating on titanium implants embedded in rodents' bone. No adverse effect or cytotoxicity of CNT addition on bone tissues and cells was observed. Normal bone growth was observed around HA-CNT-coated implants. CNT addition induces higher osseointegration as compared to HA. Elastic modulus of new bone was compared with the modulus of HA-CNT/bone Interface to understand the mechanical integrity of the implant.

引用

页码：4790 / 4799

页数：10

共 43 条

[1]

Apatite formation on carbon nanotubes [J].