Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations

被引：118

作者：

Hinohara, Kunihiko ^{[2
]}

Nakajima, Toshiaki ^{[1
,2
]}

Takahashi, Megumi ^{[1
]}

Hohda, Shigeru ^{[3
]}

Sasaoka, Taishi ^{[3
]}

Nakahara, Ken-ichi ^{[4
]}

Chida, Kouji ^{[5
]}

Sawabe, Motoji ^{[6
]}

Arimura, Takuro ^{[1
]}

Sato, Akinori ^{[1
]}

Lee, Bok-Soo ^{[7
]}

Ban, Ji-min ^{[7
]}

Yasunami, Michio ^{[1
,2
]}

Park, Jeong-Euy ^{[7
]}

Izumi, Toru ^{[3
]}

Kimura, Akinori ^{[1
,2
]}

机构：

[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Pathogenesis, Chiyoda Ku, Tokyo 1010062, Japan

[2] Tokyo Med & Dent Univ, Sch Biomed Sci, Lab Genome Divers, Tokyo, Japan

[3] Kitasato Univ, Sch Med, Dept Cardiol, Sagamihara, Kanagawa 228, Japan

[4] Nagasaki Med Ctr, Natl Hosp Org, Div Internal Med, Ohmura, Japan

[5] Tokyo Metropolitan Geriatr Med Ctr, Dept Cardiol, Tokyo, Japan

[6] Tokyo Metropolitan Geriatr Med Ctr, Dept Pathol, Tokyo, Japan

[7] Samsung Med Ctr, Div Cardiol, Seoul, South Korea

来源：

JOURNAL OF HUMAN GENETICS | 2008年 / 53卷 / 04期

关键词：

coronary artery disease; 9p21; single nucleotide polymorphism; case-control study; Japanese; Korean;

D O I：

10.1007/s10038-008-0248-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR) = 1.30, 95% confidence interval (CI); 1.13-1.49, p = 0.00027, allele count model] and Koreans (OR = 1.19, 95% CI; 1.02-1.38, p = 0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.

引用

页码：357 / 359

页数：3

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