Biochemically Distinct Vesicles from the Endoplasmic Reticulum Fuse to Form Peroxisomes

被引：142

作者：

van der Zand, Adabella ^{[1
]}

Gent, Jurgen ^{[1
]}

Braakman, Ineke ^{[1
]}

Tabak, Henk F. ^{[1
]}

机构：

[1] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands

来源：

CELL | 2012年 / 149卷 / 02期

关键词：

MATRIX PROTEIN IMPORT; SACCHAROMYCES-CEREVISIAE; MEMBRANE-PROTEINS; FLUORESCENCE COMPLEMENTATION; ANCHORED PROTEINS; LIVING CELLS; BIOGENESIS; PATHWAY; PEX3P; YEAST;

D O I：

10.1016/j.cell.2012.01.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a rule, organelles in eukaryotic cells can derive only from pre-existing organelles. Peroxisomes are unique because they acquire their lipids and membrane proteins from the endoplasmic reticulum (ER), whereas they import their matrix proteins directly from the cytosol. We have discovered that peroxisomes are formed via heterotypic fusion of at least two biochemically distinct preperoxisomal vesicle pools that arise from the ER. These vesicles each carry half a peroxisomal translocon complex. Their fusion initiates assembly of the full peroxisomal translocon and subsequent uptake of enzymes from the cytosol. Our findings demonstrate a remarkable mechanism to maintain biochemical identity of organelles by transporting crucial components via different routes to their final destination.

引用

页码：397 / 409

页数：13

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