Chiral ligands for asymmetric synthesis:: enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by chiral N-α-pyridylmethyl amino alcohols

被引：24

作者：

Yun, HY ^{[1
]}

Wu, YJ ^{[1
]}

Wu, YS ^{[1
]}

Ding, KL ^{[1
]}

Zhou, Y ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)01842-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of chiral ligands 2a-d were conveniently prepared from beta -amino alcohols through a two-step sequence and applied to catalysis of enantioselective addition of diethylzinc to benzaldehyde. Among them ligand 2c was found to show the best asymmetric induction for the reaction and catalyze the addition to various aromatic aldehydes to provide (R)-secondary alcohols in up to 98.3% ee. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：10263 / 10266

页数：4

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