A crucial test

被引:40
作者
Check, E
机构
关键词
D O I
10.1038/nm0305-243
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new drug, which uses a mechanism called RNA interference is discussed.
引用
收藏
页码:243 / 244
页数:2
相关论文
共 7 条
[1]   Inhibition of respiratory viruses by nasally administered siRNA [J].
Bitko, V ;
Musiyenko, A ;
Shulyayeva, O ;
Barik, S .
NATURE MEDICINE, 2005, 11 (01) :50-55
[2]   Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells [J].
Elbashir, SM ;
Harborth, J ;
Lendeckel, W ;
Yalcin, A ;
Weber, K ;
Tuschl, T .
NATURE, 2001, 411 (6836) :494-498
[3]   Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].
Fire, A ;
Xu, SQ ;
Montgomery, MK ;
Kostas, SA ;
Driver, SE ;
Mello, CC .
NATURE, 1998, 391 (6669) :806-811
[4]   Noise amidst the silence: off-target effects of siRNAs? [J].
Jackson, AL ;
Linsley, PS .
TRENDS IN GENETICS, 2004, 20 (11) :521-524
[5]   Gene expression - RNA interference in adult mice [J].
McCaffrey, AP ;
Meuse, L ;
Pham, TTT ;
Conklin, DS ;
Hannon, GJ ;
Kay, MA .
NATURE, 2002, 418 (6893) :38-39
[6]   Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs [J].
Soutschek, J ;
Akinc, A ;
Bramlage, B ;
Charisse, K ;
Constien, R ;
Donoghue, M ;
Elbashir, S ;
Geick, A ;
Hadwiger, P ;
Harborth, J ;
John, M ;
Kesavan, V ;
Lavine, G ;
Pandey, RK ;
Racie, T ;
Rajeev, KG ;
Röhl, I ;
Toudjarska, I ;
Wang, G ;
Wuschko, S ;
Bumcrot, D ;
Koteliansky, V ;
Limmer, S ;
Manoharan, M ;
Vornlocher, HP .
NATURE, 2004, 432 (7014) :173-178
[7]   RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia [J].
Xia, HB ;
Mao, QW ;
Eliason, SL ;
Harper, SQ ;
Martins, IH ;
Orr, HT ;
Paulson, HL ;
Yang, L ;
Kotin, RM ;
Davidson, BL .
NATURE MEDICINE, 2004, 10 (08) :816-820