Intrinsic function of a neuronal network -: a vertebrate central pattern generator

被引：196

作者：

Grillner, S ^{[1
]}

Ekeberg, Ö

El Manira, A

Lansner, A

Parker, D

Tegnér, J

Wallén, P

机构：

[1] Karolinska Inst, Nobel Inst Neurophysiol, Dept Neurosci, S-17177 Stockholm, Sweden

[2] Royal Inst Technol, Dept Numer Anal & Comp Sci, S-10044 Stockholm, Sweden

来源：

BRAIN RESEARCH REVIEWS | 1998年 / 26卷 / 2-3期

关键词：

locomotion; ion channels; networks; glycine; glutamate; tachykinin; modellin;

D O I：

10.1016/S0165-0173(98)00002-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：184 / 197

页数：14

共 74 条

[11] INCREASE IN ENDOGENOUS 5-HYDROXYTRYPTAMINE LEVELS MODULATES THE CENTRAL NETWORK UNDERLYING LOCOMOTION IN THE LAMPREY SPINAL-CORD [J].