Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus

被引：96

作者：

Reus, Gislaine Z. ^{[1
]}

Stringari, Roberto B. ^{[1
]}

de Souza, Bruna ^{[2
]}

Petronilho, Fabricia ^{[2
]}

Dal-Pizzol, Felipe ^{[2
]}

Hallak, Jaime E. ^{[3
]}

Zuardi, Antonio W. ^{[3
]}

Crippa, Jose A. ^{[3
]}

Quevedo, Joao ^{[1
]}

机构：

[1] Univ Extremo Catarinense, Lab Neurociencias, Criciuma, SC, Brazil

[2] Univ Extremo Catarinense, Lab Fisiopathol Expt, INCT TM, Programa Posgrad Ciencias Saude,Unidade Acad Cien, Criciuma, SC, Brazil

[3] Univ Sao Paulo, Dept Neurociencias & Ciencias Comportamento, INCT TM, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2010年 / 3卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

harmine; imipramine; reactive oxygen species; antioxidants activity; depression; INDUCED OXIDATIVE STRESS; CHRONIC MILD STRESS; ANIMAL-MODEL; LIPID-PEROXIDATION; BETA-CARBOLINES; PARAMETERS; DAMAGE; NEUROBIOLOGY; DEPRESSION; DISORDERS;

D O I：

10.4161/oxim.3.5.13109

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the beta-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine and harmine reduced lipid and protein oxidation, compared to control group in prefrontal cortex and hippocampus. The SOD and CAT activities increased with acute and chronic treatments with imipramine and harmine, compared to control group in prefrontal cortex and hippocampus. In conclusion, our results indicate positive effects of imipramine antidepressant and beta-carboline harmine of oxidative stress parameters, increasing SOD and CAT activities and decreasing lipid and protein oxidation.

引用

页码：325 / 331

页数：7

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