Enantiospecific total synthesis of TAN1251C and TAN1251D

被引：20

作者：

Mizutani, H ^{[1
]}

Takayama, J ^{[1
]}

Honda, T ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

来源：

SYNLETT | 2005年 / 02期

关键词：

TAN1251; alkaloid; total synthesis; aromatic oxidations; hypervalent iodine; spiro cyclization;

D O I：

10.1055/s-2004-836065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantiospecific total synthesis of TAN1251C and TAN1251D has been achieved. An aromatic oxidation reaction of a secondary amine, which is prepared from two molecules of L-tyrosine derivatives, with hypervalent iodine reagent gave a spirocyclic product as a key intermediate for the synthesis of TAN 1251C and D.

引用

页码：328 / 330

页数：3

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