The RUNX genes: Gain or loss of function in cancer

被引：382

作者：

Blyth, K ^{[1
]}

Cameron, ER ^{[1
]}

Neil, JC ^{[1
]}

机构：

[1] Univ Glasgow, Sch Vet, Inst Comparat Med, Oncol Mol Lab, Glasgow G61 1QH, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrc1607

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RUNX genes have come to prominence recently because of their roles as essential regulators of cell fate in development and their paradoxical effects in cancer, in which they can function either as tumour-suppressor genes or dominant oncogenes according to context. How can this family of transcription factors have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that regulate growth control and differentiation? And what is the evidence for a wider role for the RUNX genes in non-haematopoietic cancers?

引用

页码：376 / 387

页数：12

共 187 条

[1] The leukemic protein core binding factor β (CBFβ)-smooth-muscle myosin heavy chain sequesters CBFα2 into cytoskeletal filaments and aggregates [J].

Adya, N ;

Stacy, T ;

Speck, NA ;

Liu, PP .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (12) :7432-7443

[2] Groucho-dependent and -independent repression activities of runt domain proteins [J].

Aronson, BD ;

Fisher, AL ;

Blechman, K ;

Caudy, M ;

Gergen, JP .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (09) :5581-5587

[3] Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease [J].

Barnes, GL ;

Hebert, KE ;

Kamal, M ;

Javed, A ;

Einhorn, TA ;

Lian, JB ;

Stein, GS ;

Gerstenfeld, LC .

CANCER RESEARCH, 2004, 64 (13) :4506-4513

[4]

Barnes GL, 2003, CANCER RES, V63, P2631

[5]

Bernardin F, 2002, CANCER RES, V62, P3904

[6] AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression [J].

Bernardin-Fried, F ;

Kummalue, T ;

Leijen, S ;

Collector, MI ;

Ravid, K ;

Friedman, AD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15678-15687

[7] Unanswered questions about the role of promoter methylation in carcinogenesis [J].

Bestor, TH .

EPIGENETICS IN CANCER PREVENTION: EARLY DETECTION AND RISK ASSESSMENT, 2003, 983 :22-27

[8] Runx2:: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging [J].

Blyth, K ;

Terry, A ;

Mackay, N ;

Vaillant, F ;

Bell, M ;

Cameron, ER ;

Neil, JC ;

Stewart, M .

ONCOGENE, 2001, 20 (03) :295-302

[9] Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia [J].

Brenner, O ;

Levanon, D ;

Negreanu, V ;

Golubkov, O ;

Fainaru, O ;

Woolf, E ;

Groner, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :16016-16021

[10] Prostate cancer expression of runt-domain transcription factor Runx2, a key regulator of osteoblast differentiation and function [J].

Brubaker, KD ;

Vessella, RL ;

Brown, LG ;

Corey, E .

PROSTATE, 2003, 56 (01) :13-22

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