The RUNX genes: Gain or loss of function in cancer

被引：382

作者：

Blyth, K ^{[1
]}

Cameron, ER ^{[1
]}

Neil, JC ^{[1
]}

机构：

[1] Univ Glasgow, Sch Vet, Inst Comparat Med, Oncol Mol Lab, Glasgow G61 1QH, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrc1607

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RUNX genes have come to prominence recently because of their roles as essential regulators of cell fate in development and their paradoxical effects in cancer, in which they can function either as tumour-suppressor genes or dominant oncogenes according to context. How can this family of transcription factors have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that regulate growth control and differentiation? And what is the evidence for a wider role for the RUNX genes in non-haematopoietic cancers?

引用

页码：376 / 387

页数：12

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