The Cell Biology of Phagocytosis

被引：710

作者：

Flannagan, Ronald S. ^{[1
]}

Jaumouille, Valentin ^{[1
]}

Grinstein, Sergio ^{[1
]}

机构：

[1] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1X8, Canada

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 | 2012年 / 7卷

关键词：

antigen presentation; antimicrobial; endocytosis; innate immunity; phagosome; receptor; FC-GAMMA-R; RECEPTOR-MEDIATED PHAGOCYTOSIS; NITRIC-OXIDE SYNTHASE; PROTEIN-TYROSINE KINASE; ALDRICH-SYNDROME PROTEIN; CONTROLS PHAGOSOMAL PH; RAB COUPLING PROTEIN; PHOSPHATIDYLINOSITOL; 3-KINASE; NADPH-OXIDASE; ESCHERICHIA-COLI;

D O I：

10.1146/annurev-pathol-011811-132445

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Engulfment and destruction of invading microorganisms by phagocytosis are critical components of the innate immune response. In addition, phagocytosis is also required for the clearance of apoptotic bodies, an essential aspect of tissue homeostasis and remodeling. Here, we summarize the current knowledge of the cellular and molecular basis of phagosome formation and maturation. We discuss the manner in which phagocytosis is subverted by certain pathogens and consider congenital disorders that affect phagocyte function.

引用

页码：61 / 98

页数：38

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