Combined C-H functionalization/C-N bond formation route to carbazoles

被引：657

作者：

Tsang, WCP ^{[1
]}

Zheng, N ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 42期

关键词：

D O I：

10.1021/ja055353i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method in which a series of substituted carbazoles is efficiently produced by the combination of an amide and an arene is described. The key feature of this method is the palladium-catalyzed tandem directed C-H functionalization and amide arylation. The method tolerates substitution on either ring of the biaryl amide substrates, and the products can be assembled in a simple two-step protocol from readily available reagents. The Pd(0) species generated are reoxidized to Pd(II) in the presence of Cu(OAc)2 and an atmosphere of oxygen. Copyright © 2005 American Chemical Society.

引用

页码：14560 / 14561

页数：2

共 36 条

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