Application of liquid chromatography-mass spectrometry in the determination of oxazaphosphorines and their metabolites

被引：4

作者：

Baumann, F ^{[1
]}

Preiss, R ^{[1
]}

机构：

[1] Univ Leipzig, Inst Clin Pharmacol, D-04107 Leipzig, Germany

来源：

ANALYTICA CHIMICA ACTA | 2003年 / 492卷 / 1-2期

关键词：

oxazaphosphorine; metabolite; LC-MS; LC-MS-MS; GC-MS;

D O I：

10.1016/S0003-2670(03)00892-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This article presents an overview of the methods of bioanalysis of oxazaphosphorines and their metabolites, in particular liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS-NlS) assays. Especially for the molecules that do not contain chromophores as oxazaphosphorines the mass spectrometry took an important place in chromatographic analysis. For trace analysis the LC-MS-MS methods are particularly well suited. Above all gas chromatography-mass spectrometry (GC-MS) assays were applied for the determination of these substances, in addition, LC-MS methods and other high-performance liquid chromatography (HPLC) or GC methods were included in the consideration. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：147 / 156

页数：10

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