Carbonylative Heck Reactions Using CO Generated ex Situ in a Two-Chamber System

被引：97

作者：

Hermange, Philippe ^{[1
,2
]}

Gogsig, Thomas M. ^{[1
,2
]}

Lindhardt, Anders T. ^{[1
,2
]}

Taaning, Rolf H. ^{[1
,2
]}

Skrydstrup, Troels ^{[1
,2
]}

机构：

[1] Aarhus Univ, Ctr Insoluble Prot Struct inSPIN, Dept Chem, Langelandsgade 140, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus C, Denmark

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

PALLADIUM-CATALYZED CARBONYLATION; ARYL BROMIDES; ARYLATION; AMINOCARBONYLATION; FORMYLATION; MECHANISM; CHLORIDES; INDANONES; IODIDES; HALIDES;

D O I：

10.1021/ol200686h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A carbonylative Heck reaction of aryl iodides and styrene derivatives employing a two-chamber system using a stable, crystalline, and nontransition metal based carbon monoxide source is reported. By applying near-stoichiometric amounts of the carbon monoxide precursor, an effective exploitation of the hazardous CO gas is obtained affording chalcone derivatives in good yields. Application to isotope labeling, incorporating (CO)-C-13, was further established.

引用

收藏

页码：2444 / 2447

页数：4

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