A Palladium (II) -Catalyzed Synthesis of Spiroacetals through a One-Pot Multicomponent Cascade Reaction

被引：95

作者：

Barluenga, Jose ^{[1
]}

Mendoza, Abraham ^{[1
]}

Rodriguez, Felix ^{[1
]}

Fananas, Francisco J. ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, Unidad Asociada CSIC, E-33006 Oviedo, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 09期

关键词：

cyclization; homogeneous catalysis; multicomponent reactions; palladium; spiroacetals; PRODUCT-LIKE SCAFFOLDS; DIELS-ALDER REACTIONS; EFFICIENT SYNTHESIS; MEDIATED CYCLOISOMERIZATION; ENDO-CYCLOISOMERIZATION; EXO-CYCLOISOMERIZATION; CHEMICAL VARIATION; NATURAL-PRODUCTS; SUGAR ALKYNOLS; BERKELIC ACID;

D O I：

10.1002/anie.200805519

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Functionalized spiroacetals have been easily prepared in a one-pot three-component involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of a palladium(II) complex (see scheme). Alternatively, oxygen-substituted spiroacetals orthoesters as the third component. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1644 / 1647

页数：4

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