Protein-protein interactions in eukaryotic transcription initiation: Structure of the preinitiation complex

被引：94

作者：

Tang, H

Sun, XQ

Reinberg, D

Ebright, RH

机构：

[1] RUTGERS STATE UNIV, WAKSMAN INST, NEW BRUNSWICK, NJ 08855 USA

[2] RUTGERS STATE UNIV, DEPT CHEM, NEW BRUNSWICK, NJ 08855 USA

[3] UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, HOWARD HUGHES MED INST, NEW BRUNSWICK, NJ 08854 USA

[4] UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, DEPT BIOCHEM, NEW BRUNSWICK, NJ 08854 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 03期

关键词：

TATA-element binding protein; RNA polymerase II; general transcription factors; alanine scanning;

D O I：

10.1073/pnas.93.3.1119

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

have used alanine scanning to analyze protein-protein interactions by human TATA-element binding protein (TBP) within the transcription preinitiation complex. The results indicate that TBP interacts with RNA polymerase II and general transcription factors IIA, IIB, and IIF within the functional transcription preinitiation complex and define the determinants of TBP for each of these interactions. The results permit construction of a model for the structure of the preinitiation complex.

引用

页码：1119 / 1124

页数：6

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