Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma

被引：29

作者：

Yager, ML

Hughes, JAI

Lovicu, FJ

Gunning, PW

Weinberger, RP

O'Neill, GM

机构：

[1] Childrens Hosp, Oncol Res Unit, Westmead, NSW 2145, Australia

[2] Univ Sydney, Dept Anat & Histol, Sydney, NSW 2000, Australia

[3] Univ Sydney, Fac Med, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 05期

基金：

英国医学研究理事会;

关键词：

tropomyosin; actin; neuroblastoma; cytoskeleton;

D O I：

10.1038/sj.bjc.6601201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tropomyosin 1 ( TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TM1 does not restore actin cytoskeleton organisation in neuroblastoma cells.

引用

页码：860 / 863

页数：4