Dementia with Lewy bodies and Alzheimer's disease

被引:27
作者
Rosenberg, CK
Cummings, TJ
Saunders, AM
Widico, C
McIntyre, LM
Hulette, CM
机构
[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Med, Div Neurol,Bryan Alzheimers Dis Res Ctr, Durham, NC 27710 USA
关键词
Alzheimer's disease; apolipoprotein E; dementia with Lewy bodies;
D O I
10.1007/s004010100415
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To investigate similarities and differences between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), we undertook a demographic analysis of 277 patients from the Kathleen Price Bryan Brain Bank with an antemortem diagnosis of probable AD. Patients with additional, possibly confounding clinical and pathologic diagnoses such as infarcts, hematomas, neoplasms, and other neurodegenerative disorders, were excluded from the analysis. Neuropathologically, AD alone was present in 192 subjects (69%), and DLB was found in 85 subjects (31%). All of the DLB cases had neuropathologic evidence of AD sufficient to meet CERAD criteria for a diagnosis of definite AD plus nigral Lewy bodies. Gender, apolipoprotein E (APOE) genotype, brain weight, age at death, duration of disease and Braak stage were compared between the two groups. Statistical analyses were performed using Fisher's exact test for comparisons of categorical data and Student's t-test for comparison of means for continuous outcomes. The proportion of males and females was balanced in the combined AD and DLB populations. There was a highly statistically significant increased frequency of APOE 3/4 in males with DLB (P=0.007). We found higher brain weights in males with DLB versus males with AD (P=0.012). AD was more frequent in females and DLB was more frequent in males (P=0.019). Our findings with respect to age at death, duration of disease and Braak stage within diagnostic groups confirm previously reported findings. These data suggest that Lewy bodies are more common in males affected with dementia, especially those with the APOE 3/4 genotype.
引用
收藏
页码:621 / 626
页数:6
相关论文
共 49 条
[21]   A NEUROPATHOLOGICAL SUBSET OF ALZHEIMERS-DISEASE WITH CONCOMITANT LEWY BODY DISEASE AND SPONGIFORM CHANGE [J].
HANSEN, LA ;
MASLIAH, E ;
TERRY, RD ;
MIRRA, SS .
ACTA NEUROPATHOLOGICA, 1989, 78 (02) :194-201
[22]  
HARRINGTON CR, 1994, AM J PATHOL, V145, P1472
[23]   ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].
HUGHES, AJ ;
DANIEL, SE ;
KILFORD, L ;
LEES, AJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184
[24]   THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD) .9. A PROSPECTIVE CLINICONEUROPATHOLOGICAL STUDY OF PARKINSONS FEATURES IN ALZHEIMERS-DISEASE [J].
HULETTE, C ;
MIRRA, S ;
WILKINSON, W ;
HEYMAN, A ;
FILLENBAUM, G ;
CLARK, C .
NEUROLOGY, 1995, 45 (11) :1991-1995
[25]  
Hulette CM, 1997, ARCH PATHOL LAB MED, V121, P615
[26]   Editorial on consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute working group on diagnostic criteria for the neuropathological assessment of Alzheimer disease [J].
Hyman, BT ;
Trojanowski, JQ .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (10) :1095-1097
[27]  
JELLINGER K, 1991, ANN NY ACAD SCI, V640, P203
[28]  
JOACHIM CL, 1989, ANN NEUROL, V39, P76
[29]   Pathology of senile brains I Silver-reducing structures in the hippocampus [J].
King, LS .
ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1942, 48 (02) :241-256
[30]   DIFFUSE LEWY BODY DISEASE IN JAPAN [J].
KOSAKA, K .
JOURNAL OF NEUROLOGY, 1990, 237 (03) :197-204