Neutrophil serine proteases: potential key regulators of cell signalling during inflammation

被引：162

作者：

Wiedow, O

Meyer-Hoffert, U

机构：

[1] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17182 Solna, Sweden

[2] Univ Kiel, Dept Dermatol, D-2300 Kiel, Germany

来源：

JOURNAL OF INTERNAL MEDICINE | 2005年 / 257卷 / 04期

关键词：

cathepsin G; cytokines; elastase; proteinase; 3; receptor; TNF-alpha;

D O I：

10.1111/j.1365-2796.2005.01476.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The serine proteases cathepsin G, human leucocyte elastase and proteinase 3 are major contents of neutrophils and are released at sites of inflammation. The common picture of their function was that they do not degrade extracellular proteins specifically. Recent studies provided evidence that these proteases are able to activate specifically pro-inflammatory cytokines and lead to the activation of different receptors. Neutrophil serine proteases might therefore be important regulators of inflammatory processes and are interesting targets for new therapeutic approaches against inflammatory disorders. This review summarizes the current knowledge on the regulation of cell signalling by neutrophil serine proteases.

引用

收藏

页码：319 / 328

页数：10

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