Both interleukin-4 (IL-4) and IL-4 receptor α signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity

被引：107

作者：

Stäger, S

Alexander, J

Carter, KC

Brombacher, F

Kaye, PM

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[2] Univ Strathclyde, Dept Immunol, Glasgow, Lanark, Scotland

[3] Univ Cape Town, Fac Hlth Sci, Dept Immunol, ZA-7925 Cape Town, South Africa

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 08期

关键词：

D O I：

10.1128/IAI.71.8.4804-4807.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.

引用

页码：4804 / 4807

页数：4

共 27 条

[21] Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis [J].