Obesity and kidney disease

被引：53

作者：

Cignarelli, Mauro ^{[1
]}

Lamacchia, Olga ^{[1
]}

机构：

[1] Univ Foggia, Dept Med Sci, Unit Endocrinol & Metab Dis, I-71100 Foggia, Italy

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2007年 / 17卷 / 10期

关键词：

obesity; kidney; metabolic syndrome; remodeling; oxidative stress;

D O I：

10.1016/j.numecd.2007.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of obesity worldwide has increased dramatically. Besides, an approximately two-fold higher rate of increase in mean BMI among the incident ESRD has been reported in the US population from 1995-2002. Chronic kidney disease (CKD) prevalence increases from 2.9% among adults with an ideal BMI to 4.5% among obese adults. The development of CKD is usually the culminating result of the interaction of multiple risk factors. Obesity represents one example of a multitoxicity state and given the background of genetic susceptibility and/or reduced nephron number, overweight may initiate renal remodeling and/or accelerate kidney failure. Obesity may be the number one preventable risk factor for CKD. Weight toss has indeed been shown to improve glomerular hemodynamics and reduce urine albumin excretion. Thus, obese patients with CKD should be counseled on the benefits of weight toss. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：757 / 762

页数：6

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