The Importance of NLRP3 Inflammasome in Heart Failure

被引：153

作者：

Butts, Brittany ^{[1
]}

Gary, Rebecca A. ^{[1
]}

Dunbar, Sandra B. ^{[1
]}

Butler, Javed ^{[2
]}

机构：

[1] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA

[2] SUNY Stony Brook, Div Cardiol, Stony Brook, NY 11794 USA

来源：

JOURNAL OF CARDIAC FAILURE | 2015年 / 21卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Heart failure; inflammasome; inflammation; ACUTE MYOCARDIAL-INFARCTION; INTERLEUKIN-1-BETA INHIBITION; DNA METHYLATION; NITRIC-OXIDE; CARDIOMYOPATHY; DISEASE; DYSFUNCTION; PROTEIN; TRIAL; MOUSE;

D O I：

10.1016/j.cardfail.2015.04.014

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Patients with heart failure continue to suffer adverse health consequences despite advances in therapies over the past 2 decades. Identification of novel therapeutic targets that may attenuate disease progression is therefore needed. The inflammasome may play a central role in modulating chronic inflammation and in turn affecting heart failure progression. The inflammasome is a complex of intracellular interaction proteins that trigger maturation of proinflammatory cytokines interleukin-1 beta and interleukin-18 to initiate the inflammatory response. This response is amplified through production of tumor necrosis factor a and activation of inducible nitric oxide synthase. The purpose of this review is to discuss recent evidence implicating this inflammatory pathway in the pathophysiology of heart failure.

引用

收藏

页码：586 / 593

页数：8

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