Behavioral syndromes in Alzheimer's disease: Description and correlates

被引:205
作者
Frisoni, GB
Rozzini, L
Gozzetti, A
Binetti, G
Zanetti, O
Bianchetti, A
Trabucchi, M
Cummings, JL
机构
[1] IRCCS S Giovanni di Dio, Alzheimers Unit, I-25123 Brescia, Italy
[2] Geriatr Res Grp, Brescia, Italy
[3] Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA
关键词
behavior; Alzheimer's disease; behavioral symptoms; non-cognitive symptoms; factor analysis; heterogeneity; neuropsychiatric inventory;
D O I
10.1159/000017113
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Introduction: Behavioral disturbances in patients with Alzheimer's disease (AD) are ill-defined conditions. We hypothesize that the many behavioral disturbances hitherto described and studied might be grouped into few syndromes with separate determinants and correlates. Patients and Methods: 162 consecutive patients with probable AD admitted to a dementia unit were assessed by the UCLA Neuropsychiatric Inventory (NPI). Results: Factor analysis was carried out on NPI subscales, leading to three syndromes: 'mood', 'psychotic' and 'frontal'. Patients with the 'psychotic' syndrome were older, had older age at dementia onset, had poorer cognition, were more often males, and had faster rate of dementia progression. Patients with the 'frontal' syndrome had higher education, longer disease duration, and slower rate of progression. Discussion: Some combinations of behavioral disturbances occur more frequently together and might represent separate behavioral syndromes. Different clinical correlates of the syndromes suggest separate etiologies.
引用
收藏
页码:130 / 138
页数:9
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