Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

被引：467

作者：

Aso, Yoshinori ^{[1
]}

Sitaraman, Divya ^{[1
,2
,6
,7
]}

Ichinose, Toshiharu ^{[3
,4
]}

Kaun, Karla R. ^{[1
]}

Vogt, Katrin ^{[3
]}

Belliart-Guerin, Ghislain ^{[5
]}

Placais, Pierre-Yves ^{[5
]}

Robie, Alice A. ^{[1
]}

Yamagata, Nobuhiro ^{[3
,4
]}

Schnaitmann, Christopher ^{[3
]}

Rowell, William J. ^{[1
]}

Johnston, Rebecca M. ^{[1
]}

Ngo, Teri-T B. ^{[1
]}

Chen, Nan ^{[1
]}

Korff, Wyatt ^{[1
]}

Nitabach, Michael N. ^{[1
,2
,6
,7
]}

Heberlein, Ulrike ^{[1
]}

Preat, Thomas ^{[5
]}

Branson, Kristin M. ^{[1
]}

Tanimoto, Hiromu ^{[3
,4
]}

Rubin, Gerald M. ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Ashburn, VA 20147 USA

[2] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

[3] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany

[4] Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi 980, Japan

[5] ESPCI, Ctr Natl Rech Sci, Brain Plast Unit, F-75005 Paris, France

[6] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

[7] Yale Univ, Sch Med, Program Cellular Neurosci Neurodegenerat & Repair, New Haven, CT 06510 USA

来源：

ELIFE | 2014年 / 3卷

基金：

日本学术振兴会;

关键词：

LONG-TERM-MEMORY; SHORT NEUROPEPTIDE F; OLFACTORY MEMORY; CENTRAL COMPLEX; NMDA RECEPTORS; TEMPERATURE PREFERENCE; CONSOLIDATED MEMORY; GENETIC DISSECTION; EFFERENT NEURONS; GAMMA NEURONS;

D O I：

10.7554/eLife.04580

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by similar to 2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 types. We studied the role of MBONs in several associative learning tasks and in sleep regulation, revealing the extent to which information flow is segregated into distinct channels and suggesting possible roles for the multi-layered MBON network. We also show that optogenetic activation of MBONs can, depending on cell type, induce repulsion or attraction in flies. The behavioral effects of MBON perturbation are combinatorial, suggesting that the MBON ensemble collectively represents valence. We propose that local, stimulus-specific dopaminergic modulation selectively alters the balance within the MBON network for those stimuli. Our results suggest that valence encoded by the MBON ensemble biases memory-based action selection.

引用

页数：42

共 148 条

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Structure and response patterns of olfactory interneurons in the honeybee, Apis mellifera [J].