Hypothalamic type II iodothyronine deiodinase: a light and electron microscopic study

被引：40

作者：

Diano, S

Leonard, JL

Meli, R

Esposito, E

Schiavo, L

机构：

[1] Yale Univ, Dept Obstet & Gynecol, Sch Med, New Haven, CT 06520 USA

[2] Univ Massachusetts, Sch Med, Dept Cell & Mol Physiol, Worcester, MA 01655 USA

[3] Univ Naples Federicoll, Dept Expt Pharmacol, I-80131 Naples, Italy

来源：

BRAIN RESEARCH | 2003年 / 976卷 / 01期

关键词：

deiodinase; hypothalamus; immunocytochemistry;

D O I：

10.1016/S0006-8993(03)02692-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the central nervous system, the active form of thyroid hormone, T3, derives from the cellular uptake and intracellular 5'-monodeiodination of T4 by type II 5'-monodeiodinase (DII). Here, we report that using an antiserum raised against the C-terminus of the full-length SeDII immunolabeled cells were found in the rat hypothalamus in agreement with the DII mRNA distribution. Light and electron microscopy shows that DII is localized in astrocytes and tanycytes, supporting the hypothesis that these cells play an important role in the mediation peripheral signals, such as thyroid hormones, on hypothalamic functions. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：130 / 134

页数：5

共 19 条

[1]

AKMAYEV IG, 1976, CELL TISSUE RES, V173, P407

[2]

BLIER R, 1972, ENDOCRINE INTERACTIO, P306

[3]

BRUNI JE, 1974, J CAN SCI NEUROL, V1, P59

[4] CONGENITAL HYPOTHYROIDISM, AS STUDIED IN RATS - CRUCIAL ROLE OF MATERNAL THYROXINE BUT NOT OF 3,5,3'-TRIIODOTHYRONINE IN THE PROTECTION OF THE FETAL BRAIN [J].