Is the neutrophil the key effector cell in severe asthma?

被引：67

作者：

Kamath, AV

Pavord, ID

Ruparelia, PR

Chilvers, ER ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Med,Resp Med Div, Cambridge CB2 2QQ, England

[2] Norfolk & Norwich Univ Hosp, Dept Resp Med, Norwich, Norfolk, England

[3] Glenfield Gen Hosp, Inst Lung Hlth, Leicester LE3 9QP, Leics, England

[4] Univ Cambridge, Papworth Hosp, Sch Clin Med, Cambridge CB2 2QQ, England

来源：

THORAX | 2005年 / 60卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/thx.2005.043182

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The importance of the neutrophil as the dominant inflammatory cell in many of the non-atopic and more severe phenotypes of asthma is now clear.

引用

页码：529 / 530

页数：2

共 37 条

[1] ALLERGEN-INDUCED RECRUITMENT OF INFLAMMATORY CELLS IN LAVAGE 3 AND 24 H AFTER CHALLENGE IN ALLERGIC ASTHMATIC LUNGS [J].

AALBERS, R ;

KAUFFMAN, HF ;

VRUGT, B ;

KOETER, GH ;

DEMONCHY, JGR .

CHEST, 1993, 103 (04) :1178-1184

[2] Occupational asthma due to low molecular weight agents: eosinophilic and non-eosinophilic variants [J].

Anees, W ;

Huggins, V ;

Pavord, ID ;

Robertson, AS ;

Burge, PS .

THORAX, 2002, 57 (03) :231-236

[3] EOSINOPHILIC INFLAMMATION IN ASTHMA [J].

BOUSQUET, J ;

CHANEZ, P ;

LACOSTE, JY ;

BARNEON, G ;

GHAVANIAN, N ;

ENANDER, I ;

VENGE, P ;

AHLSTEDT, S ;

SIMONYLAFONTAINE, J ;

GODARD, P ;

MICHEL, FB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1033-1039

[4]

BRAZIL TJ, 2005, IN PRESS CLIN EXP AL

[5] Comparison of airway immunopathology of eosinophilic bronchitis and asthma [J].

Brightling, CE ;

Symon, FA ;

Birring, SS ;

Bradding, P ;

Wardlaw, AJ ;

Pavord, ID .

THORAX, 2003, 58 (06) :528-532

[6] Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response [J].

Bryan, SA ;

O'Connor, BJ ;

Matti, S ;

Leckie, MJ ;

Kanabar, V ;

Khan, J ;

Warrington, SJ ;

Renzetti, L ;

Rames, A ;

Bock, JA ;

Boyce, MJ ;

Hansel, TT ;

Holgate, ST ;

Barnes, PJ .

LANCET, 2000, 356 (9248) :2149-2153

[7] Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents [J].

Cadwallader, KA ;

Condliffe, AM ;

McGregor, A ;

Walker, TR ;

White, JF ;

Stephens, LR ;

Chilvers, ER .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3336-3344

[8] Smoking and airway inflammation in patients with mild asthma [J].

Chalmers, GW ;

MacLeod, KJ ;

Thomson, L ;

Little, SA ;

McSharry, C ;

Thomson, NC .

CHEST, 2001, 120 (06) :1917-1922

[9] Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival [J].

Cowburn, AS ;

Cadwallader, KA ;

Reed, BJ ;

Farahi, N ;

Chilvers, ER .

BLOOD, 2002, 100 (07) :2607-2616

[10]

COX G, 1995, J IMMUNOL, V154, P4719

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