Is the neutrophil the key effector cell in severe asthma?

被引:67
作者
Kamath, AV
Pavord, ID
Ruparelia, PR
Chilvers, ER [1 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Med,Resp Med Div, Cambridge CB2 2QQ, England
[2] Norfolk & Norwich Univ Hosp, Dept Resp Med, Norwich, Norfolk, England
[3] Glenfield Gen Hosp, Inst Lung Hlth, Leicester LE3 9QP, Leics, England
[4] Univ Cambridge, Papworth Hosp, Sch Clin Med, Cambridge CB2 2QQ, England
基金
英国惠康基金;
关键词
D O I
10.1136/thx.2005.043182
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The importance of the neutrophil as the dominant inflammatory cell in many of the non-atopic and more severe phenotypes of asthma is now clear.
引用
收藏
页码:529 / 530
页数:2
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共 37 条
[31]   Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects [J].
Stenfors, N ;
Pourazar, J ;
Blomberg, A ;
Krishna, MT ;
Mudway, I ;
Helleday, R ;
Kelly, FJ ;
Frew, AJ ;
Sandström, T .
RESPIRATORY MEDICINE, 2002, 96 (05) :352-358
[32]   SUDDEN-ONSET FATAL ASTHMA - A DISTINCT ENTITY WITH FEW EOSINOPHILS AND RELATIVELY MORE NEUTROPHILS IN THE AIRWAY SUBMUCOSA [J].
SUR, S ;
CROTTY, TB ;
KEPHART, GM ;
HYMA, BA ;
COLBY, TV ;
REED, CE ;
HUNT, LW ;
GLEICH, GJ .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (03) :713-719
[33]   EFFECT OF GLUCOCORTICOIDS ON HUMORAL AND CELLULAR-IMMUNITY AND ON AIRWAY INFLAMMATION IN PATIENTS WITH STEROID-DEPENDENT INTRACTABLE ASTHMA [J].
TANIZAKI, Y ;
KITANI, H ;
MIFUNE, T ;
MITSUNOBU, F ;
KAJIMOTO, K ;
SUGIMOTO, K .
JOURNAL OF ASTHMA, 1993, 30 (06) :485-492
[34]   EXACERBATIONS OF ASTHMA WITHOUT SPUTUM EOSINOPHILIA [J].
TURNER, MO ;
HUSSACK, P ;
SEARS, MR ;
DOLOVICH, J ;
HARGREAVE, FE .
THORAX, 1995, 50 (10) :1057-1061
[35]   Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma [J].
Wark, PAB ;
Johnston, SL ;
Moric, I ;
Simpson, JL ;
Hensley, MJ ;
Gibson, PG .
EUROPEAN RESPIRATORY JOURNAL, 2002, 19 (01) :68-75
[36]   Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics [J].
Wenzel, SE ;
Schwartz, LB ;
Langmack, EL ;
Halliday, JL ;
Trudeau, JB ;
Gibbs, RL ;
Chu, HW .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (03) :1001-1008
[37]   Bronchoscopic evaluation of severe asthma - Persistent inflammation associated with high dose glucocorticoids [J].
Wenzel, SE ;
Szefler, SJ ;
Leung, DYM ;
Sloan, SI ;
Rex, MD ;
Martin, RJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (03) :737-743