EFFECT OF GLUCOCORTICOIDS ON HUMORAL AND CELLULAR-IMMUNITY AND ON AIRWAY INFLAMMATION IN PATIENTS WITH STEROID-DEPENDENT INTRACTABLE ASTHMA

被引：9

作者：

TANIZAKI, Y

KITANI, H

MIFUNE, T

MITSUNOBU, F

KAJIMOTO, K

SUGIMOTO, K

机构：

[1] Department of Medicine, Misasa Medical Branch Okayama, University Medical School Misasa, Tottori

来源：

JOURNAL OF ASTHMA | 1993年 / 30卷 / 06期

关键词：

D O I：

10.3109/02770909309056758

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effects of glucocorticoids on the proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid in relation to humoral and cellular immunity were studied in 56 patients with steroid-dependent intractable asthma. To analyze the mechanism responsible for reduced numbers of BAL lymphocytes, we divided the subjects into 4 groups according to their BAL lymphocyte proportions: 0-4.9%, 5.0-9.9%, 10.0-14.9%, and 15.0-20.0%. Serum IgG levels and the peripheral lymphocyte count were significantly reduced in patients with a low proportion of BAL lymphocytes (less than 9.9%) than in those with more than 10% BAL lymphocytes. Delayed cutaneous reactivity to purified protein derivative was suppressed in patients with a low proportion of BAL lymphocytes (less than 4.9%). The mean proportion of BAL neutrophils tended to increase as the proportion of BAL lymphocytes decreased. These results show that the reduction in BAL lymphocytes produced by glucocorticoids is associated with suppressed humoral and cellular immunity, and that under such conditions the proportion of BAL neutrophils increases.

引用

页码：485 / 492

页数：8

共 34 条

[1]

Ishizaka T., Analysis of triggering events in mast cells for immunoglobulin E-mediated histamine release, J Allergy Clin Immunol, 67, (1981)

[2]

Tanizaki Y., Komagoe H., Morinaga H., Kitani H., Goda Y., Kimura I., Allergen- and anti-IgE-induced histamine release from whole blood, Int Arch Allergy Appl Immunol, 73, (1984)

[3]

Tanizaki Y., Komagoe H., Sudo M., Morinaga H., Kitani H., Nakagawa S., Takahashi K., Kimura I., Reactivity of sensitized human basophils, as expressed by histamine release, Jpn J Allergol, 33, (1984)

[4]

Durham S.R., The significance of late response in asthma, Clin Exp Allergy, 21, (1991)

[5]

Kirby J.G., Hargreave F.E., Gleich G.J., O'Byrne P.M., Bronchoalveolar cell profiles of asthmatics and nonasthmatic subjects, Am Rev Respir Dis, 136, (1987)

[6]

Lozewicz S., Gomez E., Ferguson H., Davies R.J., Inflammatory cells in the airways in mild asthma, Br Med J, 297, (1988)

[7]

Pauwels R., The relationship between airway inflammation and bronchial hyper responsiveness, Clin Exp Allergy, 19, (1989)

[8]

Beasley R.M., Roche W.R., Roberts A., Holgate S.T., Cellular events with bronchi in mild asthma and after bronchial provocation, Am Rev Respir Dis, 139, pp. 806-817, (1989)

[9]

Holgate S.T., Djukanovic R., Wilson J., Roche W., Howarth P.H., Inflammatory processes and bronchial hyperresponsiveness, Clin Exp Allergy, 23, (1991)

[10]

Gonzalez M.C., Diaz P., Galleguillos F.R., Ancic P., Cromwell O., Kay A.B., Allergen-induced recruitment of bronchoalveolar helper (OKT4) and suppressor (OKT8) T cells in asthma, Am Rev Respir Dis, 136, (1987)

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