EFFECT OF GLUCOCORTICOIDS ON HUMORAL AND CELLULAR-IMMUNITY AND ON AIRWAY INFLAMMATION IN PATIENTS WITH STEROID-DEPENDENT INTRACTABLE ASTHMA

被引：9

作者：

TANIZAKI, Y

KITANI, H

MIFUNE, T

MITSUNOBU, F

KAJIMOTO, K

SUGIMOTO, K

机构：

[1] Department of Medicine, Misasa Medical Branch Okayama, University Medical School Misasa, Tottori

来源：

JOURNAL OF ASTHMA | 1993年 / 30卷 / 06期

关键词：

D O I：

10.3109/02770909309056758

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effects of glucocorticoids on the proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid in relation to humoral and cellular immunity were studied in 56 patients with steroid-dependent intractable asthma. To analyze the mechanism responsible for reduced numbers of BAL lymphocytes, we divided the subjects into 4 groups according to their BAL lymphocyte proportions: 0-4.9%, 5.0-9.9%, 10.0-14.9%, and 15.0-20.0%. Serum IgG levels and the peripheral lymphocyte count were significantly reduced in patients with a low proportion of BAL lymphocytes (less than 9.9%) than in those with more than 10% BAL lymphocytes. Delayed cutaneous reactivity to purified protein derivative was suppressed in patients with a low proportion of BAL lymphocytes (less than 4.9%). The mean proportion of BAL neutrophils tended to increase as the proportion of BAL lymphocytes decreased. These results show that the reduction in BAL lymphocytes produced by glucocorticoids is associated with suppressed humoral and cellular immunity, and that under such conditions the proportion of BAL neutrophils increases.

引用

页码：485 / 492

页数：8

共 34 条

[11]

Kelly C.A., Ward C., Stenton C.S., Bird G., Hendrick D.J., Walters E.H., Numbers and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma, and their relationship to airway responsiveness, Thorax, 43, (1988)

[12]

Kelly C.A., Stenton S.C., Ward G., Hendrick D.J., Walters E.H., Lymphocyte subsets in bronchoalveolar lavage fluid obtained from stable asthmatics, and their correlations with bronchial responsiveness, Clin Exp Allergy, 19, (1989)

[13]

Wardlaw A.J., Kay A.B., The role of the eosinophil in the pathogenesis of asthma, Allergy, 42, (1989)

[14]

de Monchy S.G.R., Kauffman E.F., Venge P., Koefer K., Sluiter H.J., Jansen H.M., de Vries K., Bronchoalveolar eosinophilia during allergen-induced late asthmatic reaction, Am Rev Respir Dis, 131, (1985)

[15]

Wardlaw A.J., Dunnette S., Gleich G.J., Collins J.V., Kay A.B., Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma, Am Rev Respir Dis, 177, (1988)

[16]

Boichot E., Lagente V., Carre C., Waltmann P., Huerta M.J.M., Braquet P., Bronchial hyperresponsiveness and cellular infiltration in the lung of guineapigs sensitized and challenged by aerosol, Clin Exp Allergy, 21, (1991)

[17]

Fabbri L.M., Baschetto P., Zocca E., Milani G., Pivirotto F., Piebani M., Burlina A., Licata B., Mapp C., Bron-choalveolar neutrophilia during late asthmatic reactions induced by toluene di-isocyanate, Am Rev Respir Dis, 136, (1987)

[18]

Wardlaw A.J., Hay H., Cromwell O., Collins J.V., Kay A.B., Leukotrienes, LTC4 and LTB4, in bronchoaive-olar lavage in bronchial asthma and other respiratory diseases, J Allergy Clin Immunol, 84, (1989)

[19]

Chan-Yeung M., Chan H., Tse K.S., Salari H., Lam S., Histamine and leukotrienes release in bronchoalve-olar fluid during plicatic acid-induced bronchocon-striction, J Allergy Clin Immunol, 84, (1989)

[20]

Wenzel S.E., Westcott J.Y., Larsen G.L., Bronchoalveo-lar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: Relationship to the development of late asthmatic responses, J Allergy Clin Immunol, 87, (1991)

← 1 2 3 4 →