Activity, regulation, and intracellular localization of RGS proteins

被引：48

作者：

Chidiac, P ^{[1
]}

Roy, AA ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada

来源：

RECEPTORS & CHANNELS | 2003年 / 9卷 / 03期

关键词：

G protein; G protein coupled receptor; RGS protein; signal transduction;

D O I：

10.3109/10606820308244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RGS proteins attenuate the activities of heterotrimeric G proteins largely by promoting the hydrolysis of the activating nucleotide GTP. This review discusses the interactions of RGS proteins and G proteins and how those interactions are regulated by a variety of factors including auxiliary proteins and other cellular constituents, posttranslational modifications, and intracellular localization patterns. In addition, we discuss progress that has been made toward understanding the roles that RGS proteins play in vivo, and how they may serve to govern responses to G protein coupled receptors upon acute and prolonged activation by agonists.

引用

页码：135 / 147

页数：13

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