Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers

被引：473

作者：

Leroueil, Pascale R. ^{[1
,4
]}

Berry, Stephanie A. ^{[2
,4
]}

Duthie, Kristen ^{[1
,2
,4
]}

Han, Gang ^{[5
]}

Rotello, Vincent M. ^{[5
]}

McNerny, Daniel Q. ^{[3
,4
]}

Baker, James R., Jr. ^{[4
]}

Orr, Bradford G. ^{[2
,4
]}

Holl, Mark M. Banaszak ^{[1
,4
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48019 USA

[2] Univ Michigan, Dept Phys, Ann Arbor, MI 48019 USA

[3] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48019 USA

[4] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48019 USA

[5] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 02期

关键词：

D O I：

10.1021/nl0722929

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating pepide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH2, SiO2-NH2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.

引用

页码：420 / 424

页数：5

共 44 条

[1] Behaviour of nanoparticle (ultrafine) titanium dioxide pigments and stabilisers on the photooxidative stability of water based acrylic and isocyanate based acrylic coatings [J].

Allen, NS ;

Edge, M ;

Ortega, A ;

Liauw, CM ;

Stratton, J ;

McIntyre, RB .

POLYMER DEGRADATION AND STABILITY, 2002, 78 (03) :467-478

[2] Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding [J].

Bagwe, RP ;

Hilliard, LR ;

Tan, WH .

LANGMUIR, 2006, 22 (09) :4357-4362

[3] The impact of nanoscience on heterogeneous catalysis [J].

Bell, AT .

SCIENCE, 2003, 299 (5613) :1688-1691

[4] Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo [J].

Bielinska, AU ;

Yen, A ;

Wu, HL ;

Zahos, KM ;

Sun, R ;

Weiner, ND ;

Baker, JR ;

Roessler, BJ .

BIOMATERIALS, 2000, 21 (09) :877-887

[5] Studies on the internalization mechanism of cationic cell-penetrating peptides [J].

Drin, G ;

Cottin, S ;

Blanc, E ;

Rees, AR ;

Temsamani, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (33) :31192-31201

[6] TAT-MEDIATED DELIVERY OF HETEROLOGOUS PROTEINS INTO CELLS [J].

FAWELL, S ;

SEERY, J ;

DAIKH, Y ;

MOORE, C ;

CHEN, LL ;

PEPINSKY, B ;

BARSOUM, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :664-668

[7] In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. [J].

Fischer, D ;

Li, YX ;

Ahlemeyer, B ;

Krieglstein, J ;

Kissel, T .

BIOMATERIALS, 2003, 24 (07) :1121-1131

[8] In vitro antimicrobial activity of MSI-78, a magainin analog [J].

Fuchs, PC ;

Barry, AL ;

Brown, SD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (05) :1213-1216

[9] Modeling the thermodynamics of the interaction of nanoparticles with cell membranes [J].

Ginzburg, Valedy V. ;

Balijepailli, Sudhakar .

NANO LETTERS, 2007, 7 (12) :3716-3722

[10] Toxicity of gold nanoparticles functionalized with cationic and anionic side chains [J].

Goodman, CM ;

McCusker, CD ;

Yilmaz, T ;

Rotello, VM .

BIOCONJUGATE CHEMISTRY, 2004, 15 (04) :897-900

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