Acquired prion disease: iatrogenic CJD, variant CJD, kuru

被引:143
作者
Will, RG [1 ]
机构
[1] Western Gen Hosp, Dept Clin Neurosci, Natl CJD Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland
关键词
D O I
10.1093/bmb/66.1.255
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Human prion diseases can be classified as sporadic, hereditary or acquired. The cause of sporadic Creutzfeldt-Jakob disease (CJD) is unknown, hereditary cases are associated with mutations of the prion protein gene (PRNP) and acquired forms are caused by the transmission of infection from human to human or, as a zoonosis, from cattle to human. Although acquired forms of human prion disease are rare, the transmission of a fatal and untreatable neurological disorder has had major implications for public health and public policy.
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页码:255 / 265
页数:11
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