Genetic variation in 8q24 associated with risk of colorectal cancer

被引：56

作者：

Gruber, Stephen B.

Moreno, Victor

Rozek, Laura S.

Rennert, Hedy S.

Lejbkowicz, Flavio

Bonner, Joseph D.

Greenson, Joel K.

Giordano, Thomas J.

Fearon, Eric R.

Rennert, Gad

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Div Med & Mol Genet, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Epidemiol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

[4] Catalan Inst Oncol, Barcelona, Spain

[5] Technion Israel Inst Technol, Carmel Med Ctr, Haifa, Israel

[6] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel

[7] Technion Israel Inst Technol, CHS Natl Canc Control Ctr, IL-31096 Haifa, Israel

[8] Technion Israel Inst Technol, Dept Community Med & Epidemiol, IL-31096 Haifa, Israel

[9] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

CANCER BIOLOGY & THERAPY | 2007年 / 6卷 / 07期

关键词：

colorectal cancer; genetics; epidemiology; risk; kin-cohort analysis;

D O I：

10.4161/cbt.6.7.4704

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome 8q24 harbors oncogenes known to be involved in pathogenesis of colorectal cancer (CRC) as well as uncharacterized genetic variants that have recently been shown to influence inherited risk of prostate cancer. In a population-based case-control study of colorectal cancer in northern Israel, we investigated the association between variation in 8q24 and risk of CRC. Among 1,861 incident cases and 1,937 population-based controls matched on age, gender, ethnicity, and clinic, rs 10505477 was associated with risk of CRC in a dominant model, with an odds ratio = 1.23, 95% confidence interval = 1.05-1.43, (p = 0.008). This association was independently validated in an analysis of cancer among relatives of carriers of the risk allele, with a hazard ratio of 3.2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs 10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies.

引用

页码：1143 / 1147

页数：5

共 17 条

[1] HOMOGENEOUSLY STAINING CHROMOSOMAL REGIONS CONTAIN AMPLIFIED COPIES OF AN ABUNDANTLY EXPRESSED CELLULAR ONCOGENE (C-MYC) IN MALIGNANT NEUROENDOCRINE CELLS FROM A HUMAN-COLON CARCINOMA [J].

ALITALO, K ;

SCHWAB, M ;

LIN, CC ;

VARMUS, HE ;

BISHOP, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1707-1711

[2] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[3] A marginal likelihood approach for estimating penetrance from kin-cohort designs [J].

Chatterjee, N ;

Wacholder, S .

BIOMETRICS, 2001, 57 (01) :245-252

[4] USING AGE OF ONSET TO DISTINGUISH BETWEEN SUBFORMS OF BREAST-CANCER [J].

CLAUS, EB ;

RISCH, NJ ;

THOMPSON, WD .

ANNALS OF HUMAN GENETICS, 1990, 54 :169-177

[5] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[6] Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles [J].

Giordano, TJ ;

Shedden, KA ;

Schwartz, DR ;

Kuick, R ;

Taylor, JMG ;

Lee, N ;

Misek, DE ;

Greenson, JK ;

Kardia, SLR ;

Beer, DG ;

Rennert, G ;

Cho, KR ;

Gruber, SB ;

Fearon, ER ;

Hanash, S .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (04) :1231-1238

[7] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

[8] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[9] A simple method for the routine detection of somatic quantitative genetic alterations in colorectal cancer [J].

Killian, Audrey ;

Di Fiore, Frederic ;

Le Pessot, Florence ;

Blanchard, France ;

lamy, Aude ;

Raux, Gregory ;

Flaman, Jean-Michel ;

Paillot, Bernard ;

Michel, Pierre ;

Sabourin, Jean-Christophe ;

Tuech, Jean-Jacoues ;

Michot, Francis ;

Kerckaert, Jean-Pierre ;

Sesboue, Richard ;

Frebourg, Thierry .

GASTROENTEROLOGY, 2007, 132 (02) :645-653

[10] Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis [J].

Killian, Audrey ;

Sarafan-Vasseur, Nasrin ;

Sesboue, Richard ;

Le Pessot, Florence ;

Blanchard, France ;

Lamy, Aude ;

Laurent, Michelle ;

Flaman, Jean-Michel ;

Frebourg, Thierry .

GENES CHROMOSOMES & CANCER, 2006, 45 (09) :874-881

← 1 2 →