Degree of Polymerization of Inulin-Type Fructans Differentially Affects Number of Lactic Acid Bacteria, Intestinal Immune Functions, and Immunoglobulin A Secretion in the Rat Cecum

被引：106

作者：

Ito, Hiroyuki ^{[1
]}

Takemura, Naoki ^{[2
]}

Sonoyama, Kei ^{[2
]}

Kawagishi, Hirokazu ^{[3
]}

Topping, David L. ^{[4
]}

Conlon, Michael A. ^{[4
]}

Morita, Tatsuya ^{[1
]}

机构：

[1] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Shizuoka 4228529, Japan

[2] Hokkaido Univ, Div Appl Biosci, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan

[3] Shizuoka Univ, Grad Sch Sci & Technol, Shizuoka 4228529, Japan

[4] CSIRO Food & Nutr Sci, Adelaide, SA 5000, Australia

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 10期

关键词：

fructan; immunoglobulin A; lactobacillus; cecum; rats; GLUCAGON-LIKE PEPTIDE-1; INDIGESTIBLE SACCHARIDES; T-CELLS; IGA; OLIGOSACCHARIDES; OLIGOFRUCTOSE; MICE; FRUCTOOLIGOSACCHARIDES; MICROFLORA; RESPONSES;

D O I：

10.1021/jf200859z

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

This study examined the role of degree of polymerization (DP) of inulin-fructans in modulating the interaction between lactic acid bacteria and IgA cecal secretion. Rats were fed a control diet or a diet containing one of the fructans with different DP. Consuming fructans increased the cecal IgA concentrations in the order DP4 > DP8 > DP16. Cecal lactobacilli counts were higher in DP4, DP8, and DP16, whereas bifidobacteria were higher in DP8, DP16, and DP23. Cecal IgA concentrations were correlated with cecal lactobacilli counts (P < 0.01). DP4, DP8, and DP16, but not DP23, significantly increased IgA-producing plasma cells In the cecal mucosa. IFN-gamma and IL-10 production in the cecal CD4(+) T cells was enhanced solely in DP4. The results show that fructans with lower DP enhance cecal IgA secretion and increase the plasma cells and suggest that the increased lactobacilli may contribute to the stimulation of cecal IgA secretion.

引用

页码：5771 / 5778

页数：8

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