mTOR inhibitors: An overview

被引：142

作者：

Neuhaus, P ^{[1
]}

Klupp, J ^{[1
]}

Langrehr, JM ^{[1
]}

机构：

[1] Humboldt Univ, Charite Virchow, Dept Surg, D-13353 Berlin, Germany

来源：

LIVER TRANSPLANTATION | 2001年 / 7卷 / 06期

关键词：

D O I：

10.1053/jlts.2001.24645

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inhibitors of the mammalian target of rapamycin are a new class of immunosuppressants. In contrast to other macrolides, such as tacrolimus and cyclosporine A, they do not inhibit calcineurin and thus signal I of T-cell activation. By inhibiting signal III, the mechanism of action and side effects of sirolimus (rapamycin) and its derivative RAD are distinct from other immunosuppressants. Reports of synergism with cyclosporine A and tacrolimus in preclinical and clinical studies, avoidance of nephrotoxicity, and possible treatment or prevention of chronic allograft rejection are leading to high expectations for this new class of immunosuppressants. Furthermore, studies evaluating tolerance induction are being conducted. This review summarizes preclinical and clinical results published to date and exploits the future value of sirolimus and RAD for clinical transplantation.

引用

页码：473 / 484

页数：12

共 118 条

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