Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat

被引：11

作者：

Cantarella, G

Martinez, G

Cutuli, VM

Loreto, C

D'Alcamo, M

Prato, A

Amico-Roxas, M

Bernardini, R

Clementi, G

机构：

[1] Univ Catania, Fac Med, Dipartimento Farmacol Sperimentale & Clin, I-95125 Catania, Italy

[2] Catania Univ, Sch Med, Dept Anat Diagnost Pathol Forens Med Publ Hlth, I-95126 Catania, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 518卷 / 2-3期

关键词：

gastric damage; hepatocyte growth factor; COX-2 (cyclooxygenase-2); adrenomedullin; CGRP (calcitonin gene-related peptide) receptor;

D O I：

10.1016/j.ejphar.2005.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Here we show the increased hepatocyte growth factor (HGF) and cyclooxygenase-2 (COX-2) expression in gastric mucosa of rats which have developed a reserpine-induced ulcer. Such an increase of HGF and COX-2 expression was blunted in rats pretreated with adrenomedullin. Pretreatment with adrenomedullin and the adrenomedullin(22-52) fragment did not result in changes of HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Pretreatment with adrenomedullin and the calcitonin gene-related peptide(8-37) fragment (CGRP(8-37)) increased HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Our results suggest that the inhibitory effect of adrenomedullin on the expression of HGF and COX-2 is mediated by CGRP receptors. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：221 / 226

页数：6

共 22 条

[1]

[Anonymous], DRUGS NEWS PERSPECT

[2]

Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation [J].