Gastroprotective effect of adrenomedullin administered subcutaneously in the rat

被引：26

作者：

Clementi, G ^{[1
]}

Caruso, A ^{[1
]}

Cutuli, VMC ^{[1
]}

Mangano, NG ^{[1
]}

Salomone, S ^{[1
]}

Lempereur, L ^{[1
]}

Prato, A ^{[1
]}

Matera, M ^{[1
]}

Amico-Roxas, M ^{[1
]}

机构：

[1] Catania Univ, Sch Med, Dept Expt & Clin Pharmacol, Catania, Italy

来源：

PEPTIDES | 2002年 / 23卷 / 06期

关键词：

adrenomedullin; gastroprotective activity; subcutaneous administration; somatostatin transmission;

D O I：

10.1016/S0196-9781(02)00048-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Subcutaneous injections of adrenomedullin prevented reserpine-induced gastric mucosal damage in a dose-dependent manner (1-1000 ng/kg), but did not interfere with the lesions produced by ethanol administration. In pylorus-ligated rats adrenomedullin significantly reduced gastric volume, total and free acid output as well as ulcer formation. The gastroprotective activity of adrenomedullin was not present in rats pretreated with cysteamine. These results suggest that adrenomedullin exerts its antiulcer effect, when it is administered subcutaneously (s.c.), probably by a mechanism which involves somatostatin related transmission. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1149 / 1153

页数：5

共 27 条

[1] Effects of centrally or peripherally injected adrenomedullin on reserpine-induced gastric lesions [J].

Clementi, G ;

Caruso, A ;

Cutuli, VMC ;

de Bernardis, E ;

Prato, A ;

Mangano, NG ;

Amico-Roxas, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 360 (01) :51-54

[2] PROTECTIVE EFFECTS OF CALCITONIN-GENE-RELATED PEPTIDE IN DIFFERENT EXPERIMENTAL-MODELS OF GASTRIC-ULCERS [J].

CLEMENTI, G ;

AMICOROXAS, M ;

CARUSO, A ;

CUTULI, VMC ;

MAUGERI, S ;

PRATO, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 238 (01) :101-104

[3] A CRITICAL-EVALUATION OF CYSTEAMINE AS A TOOL TO DEPLETE SOMATOSTATIN IN THE RAT CENTRAL NERVOUS-SYSTEM [J].

COOK, LL ;

BISSETTE, G ;

DOLE, K ;

NEMEROFF, CB .

ENDOCRINOLOGY, 1989, 124 (02) :855-861

[4] CALCITONIN GENE-RELATED PEPTIDE - A POTENT AND SELECTIVE STIMULATOR OF GASTROINTESTINAL SOMATOSTATIN SECRETION [J].

DUNNING, BE ;

TABORSKY, GJ .

ENDOCRINOLOGY, 1987, 120 (05) :1774-1781

[5]

GROVES WG, 1974, RES COMMUN CHEM PATH, V9, P523

[6] AMYLIN GIVEN BY CENTRAL AND PERIPHERAL ROUTES INHIBITS ACID GASTRIC-SECRETION [J].

GUIDOBONO, F ;

COLUZZI, M ;

PAGANI, F ;

PECILE, A ;

NETTI, C .

PEPTIDES, 1994, 15 (04) :699-702

[7] Adrenomedullin, a multifunctional regulatory peptide [J].

Hinson, JP ;

Kapas, S ;

Smith, DM .

ENDOCRINE REVIEWS, 2000, 21 (02) :138-167

[8] DISTRIBUTION AND CHARACTERIZATION OF IMMUNOREACTIVE ADRENOMEDULLIN IN HUMAN TISSUE AND PLASMA [J].

ICHIKI, Y ;

KITAMURA, K ;

KANGAWA, K ;

KAWAMOTO, M ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 338 (01) :6-10

[9]

Kagoshima M, 1982, Nihon Yakurigaku Zasshi, V80, P231

[10] Central action of adrenomedullin to prevent ethanol-induced gastric injury through vagal pathways in rats [J].

Kaneko, H ;

Mitsuma, T ;

Nagai, H ;

Mori, S ;

Iyo, T ;

Kusugami, K ;

Taché, Y .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (06) :R1783-R1788

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