Acute hepatitis caused by a novel strain of hepatitis E virus most closely related to United States strains

被引：32

作者：

Kabrane-Lazizi, Y

Zhang, MD

Purcell, RH

Miller, KD

Davey, RT

Emerson, SU ^{[1
]}

机构：

[1] NIAID, Infect Dis Lab, Hepatitis Viruses Sect, NIH, Bethesda, MD 20892 USA

[2] NIAID, Infect Dis Lab, Mol Hepatitis Sect, NIH, Bethesda, MD 20892 USA

[3] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[4] NIH, Ctr Clin, Dept Crit Care Med, Bethesda, MD 20892 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2001年 / 82卷

关键词：

D O I：

10.1099/0022-1317-82-7-1687

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A unique hepatitis E virus (HEV) strain was identified as the aetiological agent of acute hepatitis in a United States (US) patient who had recently returned from vacation in Thailand, a country in which HEV is endemic. Sequence comparison showed that this HEV strain was most similar, but not identical, to the swine and human HEV strains recovered in the US. Phylogenetic analysis revealed that this new HEV isolate was closer to genotype 3 strains than to the genotype 1 strains common in Asia. The fact that this HEV was closely related to strains recovered in countries where HEV is not endemic and was highly divergent from Asian HEV strains raises the questions of where the patient's infection was acquired and of whether strains are geographically as localized as once thought.

引用

页码：1687 / 1693

页数：7

共 47 条

[1]

Arankalle V A, 1994, J Viral Hepat, V1, P125, DOI 10.1111/j.1365-2893.1994.tb00111.x

[2] Epidemiology of hepatitis E virus infection [J].