Characterization of alpha(1)-adrenoceptor subtypes in rat spinal cord

被引：34

作者：

Wada, T

Otsu, T

Hasegawa, Y

Mizuchi, A

Ono, H

机构：

[1] SCI UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACOL,SHINJUKU KU,TOKYO 162,JAPAN

[2] UNIV TOKYO,DEPT PHARM,BRANCH HOSP,FAC MED,BUNKYO KU,TOKYO 112,JAPAN

[3] MITSUI PHARMACEUT INC,INST BIOL SCI,MOBARA,CHIBA 297,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 312卷 / 02期

关键词：

spinal cord; alpha(1)-adrenoceptor subtype; BMY; 7378; 5-methyl-urapidil; H-3]prazosin; (rat);

D O I：

10.1016/0014-2999(96)00570-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The a, adrenoceptor subtypes in ventral and dorsal horns of rat lumbar spinal cord were studied. High concentrations of the alpha(1D)-adrenoceptor antagonist, BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride), displaced bound [H-3]prazosin in a single-site manner and the binding affinity was close to those for alpha(1A)- and alpha(1B)-adrenoceptor binding sites. 5-Methyl-urapidil displaced bound [H-3]prazosin in a two-site manner and the high and low affinities were close to those of alpha(1A)- and alpha(1B)-adrenoceptor binding sites, respectively. The alpha(1)-adrenoceptor subtype populations of ventral and dorsal horns did not differ. The alpha(1A)- and alpha(1B)-adrenoceptor populations comprised 70% and 30%, respectively, of the total and very few alpha(1D)-adrenoceptors and a were detected.

引用

页码：263 / 266

页数：4