Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma

被引：38

作者：

Chang, Hong

Ning, Yi

Qi, Xiaoying

Yeung, Joanna

Xu, Wei

机构：

[1] Toronto Gen Hosp, Univ Hlth Network, Dept Haematol Lab, Toronto, ON M5G 2C4, Canada

[2] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA

[3] Univ Hlth Network, Dept Biostat, Toronto, ON, Canada

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 01期

关键词：

multiple myeloma; 1p21; CDC14A; fluorescence in situ hybridization; prognosis;

D O I：

10.1111/j.1365-2141.2007.06750.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The combination of fluorescence in situ hybridization with cytoplasmic light chain detection identified chromosome 1p21 deletion in 18 (20%) of 87 patients with multiple myeloma. 1p21 deletion was associated with higher serum calcium level, 13q deletion, and t(4;14). Patients with 1p21 deletions had a significantly shorter progression-free survival (PFS) (median 10.5 vs. 22.3 months, P = 0.0002) and shorter overall survival (OS) (median 33.9 months vs. not reached, P = 0.002) than those without 1p21 deletions. On multivariate analysis, which included deletions of 13q, TP53, t(4;14) and CKS1B amplification, 1p21 deletion remained as an independent risk factor for PFS (P = 0.01) and OS (P = 0.04).

引用

页码：51 / 54

页数：4

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