Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

被引:137
作者
Volkow, ND [1 ]
Wang, GJ
Fowler, JS
Ding, YS
Gur, RC
Gatley, J
Logan, J
Moberg, PJ
Hitzemann, R
Smith, G
Pappas, N
机构
[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
[2] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA
[3] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA
[4] Univ Penn, Sch Med, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USA
关键词
D O I
10.1002/ana.410440125
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.
引用
收藏
页码:143 / 147
页数:5
相关论文
共 20 条
[1]   Long-term changes of striatal dopamine D-2 receptors in patients with Parkinson's disease: A study with positron emission tomography and [C-11]Raclopride [J].
Antonini, A ;
Schwarz, J ;
Oertel, WH ;
Pogarell, O ;
Leenders, KL .
MOVEMENT DISORDERS, 1997, 12 (01) :33-38
[2]   Age-related and regional differences in dopamine transporter mRNA expression in human midbrain [J].
Bannon, MJ ;
Whitty, CJ .
NEUROLOGY, 1997, 48 (04) :969-977
[3]   LEARNING CAUSES SYNAPTOGENESIS, WHEREAS MOTOR-ACTIVITY CAUSES ANGIOGENESIS, IN CEREBELLAR CORTEX OF ADULT-RATS [J].
BLACK, JE ;
ISAACS, KR ;
ANDERSON, BJ ;
ALCANTARA, AA ;
GREENOUGH, WT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5568-5572
[4]   Alterations in synaptic strength preceding axon withdrawal [J].
Colman, H ;
Nabekura, J ;
Lichtman, JW .
SCIENCE, 1997, 275 (5298) :356-361
[5]   Increased density of multiple-head dendritic spines on medium-sized spiny neurons of the striatum in rats reared in a complex environment [J].
Comery, TA ;
Stamoudis, CX ;
Irwin, SA ;
Greenough, WT .
NEUROBIOLOGY OF LEARNING AND MEMORY, 1996, 66 (02) :93-96
[6]   DOPAMINE RECEPTOR-BINDING ENHANCEMENT ACCOMPANIES LESION-INDUCED BEHAVIORAL SUPERSENSITIVITY [J].
CREESE, I ;
BURT, DR ;
SNYDER, SH .
SCIENCE, 1977, 197 (4303) :596-598
[7]   OPERANTLY CONDITIONED RUNNING - EFFECTS ON BRAIN CATECHOLAMINE CONCENTRATIONS AND RECEPTOR DENSITIES IN THE RAT [J].
DECASTRO, JM ;
DUNCAN, G .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1985, 23 (04) :495-500
[8]   PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease [J].
Ginovart, N ;
Lundin, A ;
Farde, L ;
Halldin, C ;
Backman, L ;
Swahn, CG ;
Pauli, S ;
Sedvall, G .
BRAIN, 1997, 120 :503-514
[9]   Oxidative stress and age-related neuronal deficits [J].
Joseph, JA ;
Denisova, N ;
VillalobosMolina, R ;
Erat, S ;
Strain, J .
MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1996, 28 (1-3) :35-40
[10]   AGING PRODUCES A SPECIFIC PATTERN OF STRIATAL DOPAMINE LOSS - IMPLICATIONS FOR THE ETIOLOGY OF IDIOPATHIC PARKINSONS-DISEASE [J].
KISH, SJ ;
SHANNAK, K ;
RAJPUT, A ;
DECK, JHN ;
HORNYKIEWICZ, O .
JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) :642-648