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Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging
被引:137
作者:

Volkow, ND
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Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Wang, GJ
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Fowler, JS
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Ding, YS
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Gur, RC
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Gatley, J
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Logan, J
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Moberg, PJ
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Hitzemann, R
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Smith, G
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

Pappas, N
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机构: Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
机构:
[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
[2] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA
[3] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA
[4] Univ Penn, Sch Med, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USA
关键词:
D O I:
10.1002/ana.410440125
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.
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页码:143 / 147
页数:5
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