Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging

被引：137

作者：

Volkow, ND ^{[1
]}

Wang, GJ

Fowler, JS

Ding, YS

Gur, RC

Gatley, J

Logan, J

Moberg, PJ

Hitzemann, R

Smith, G

Pappas, N

机构：

[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

[2] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA

[3] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA

[4] Univ Penn, Sch Med, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USA

来源：

ANNALS OF NEUROLOGY | 1998年 / 44卷 / 01期

关键词：

D O I：

10.1002/ana.410440125

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aging of the human brain is associated with a decline in dopamine (DA) function, generally interpreted as reflecting DA cell loss. Positron emission tomography studies revealed that in healthy individuals, the age-related losses in DA transporters (presynaptic marker) were associated with losses in D2 receptors (postsynaptic marker) rather than with increases as is known to occur with DA cell loss. This association was specific for DA synaptic markers, because they were not correlated with striatal metabolism. Furthermore, the association was independent of age, suggesting that a common mechanism regulates the expression of receptors and transporters irrespective of age.

引用

页码：143 / 147

页数：5

共 20 条

[11] GRAPHICAL ANALYSIS OF REVERSIBLE RADIOLIGAND BINDING FROM TIME ACTIVITY MEASUREMENTS APPLIED TO [N-C-11-METHYL]-(-)-COCAINE PET STUDIES IN HUMAN-SUBJECTS [J].