Engineering the nanoparticle-protein interface: applications and possibilities

被引:156
作者
Rana, Subinoy [1 ]
Yeh, Yi-Cheun [1 ]
Rotello, Vincent M. [1 ]
机构
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
关键词
FUNCTIONALIZED GOLD NANOPARTICLES; MAGNETIC GLYCO-NANOPARTICLES; QUANTUM DOTS; CYTOCHROME-C; FLUORESCENT PROTEIN; TAGGED PROTEINS; RECOGNITION; DIFFERENTIATION; IMMOBILIZATION; MONOLAYER;
D O I
10.1016/j.cbpa.2010.10.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Covalent and non-covalent conjugation of proteins to nanoparticles provides access to functional hybrid systems with applications in biotechnology, medicine, and catalysis. The creation of effective conjugates requires the retention of protein structure and function, a challenging task. In this review we discuss successes, challenges and opportunities in the area of protein-nanoparticle bioconjugation.
引用
收藏
页码:828 / 834
页数:7
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