Cytotoxic 7,20-epoxy ent-kauranoids from Isodon xerophilus

被引：33

作者：

Hou, AJ

Zhao, QS

Li, ML

Jiang, B

Lin, ZW

Sun, HD ^{[1
]}

Zhou, YP

Lu, Y

Zheng, QT

机构：

[1] Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China

[2] Kunming Med Coll, Yunnan Lab Pharmacol & Nat Prod, Kunming 650031, Yunnan, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY | 2001年 / 58卷 / 01期

关键词：

Isodon xerophilus; Labiatae; ent-kaurane diterpenoids; xerophilusins G; I-K;

D O I：

10.1016/S0031-9422(01)00164-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four 7.20-epoxy ent-kaurane diterpenoids. xerophilusins G (1) and I-K (2-4). were isolated from the leaves of Isodon xerophilus. along with four known ones, enanderianin C (5), rosthorin A (6), longikaurin B (7), and rabdoternin D (8). Their structures were determined primarily using NMR spectroscopic techniques. The structure and stereochemistry of 3 were confirmed by X-ray crystallography. Compounds 4 and 7 exhibited broad cytotoxicity against four kinds of human tumor cells (K562, HL-60, HCT, and MKN-28 cells) in the range of 2.23-15.35 and 0.30 8.61 mug/ml, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：179 / 183

页数：5

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