Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy

被引:36
作者
Rice, L
Nichol, JL
McMillan, R
Roskos, LK
Bacile, M
机构
[1] Amgen Inc, Thousand Oaks, CA 91320 USA
[2] Baylor Coll Med, Houston, TX 77030 USA
[3] Scripps Res Inst, La Jolla, CA USA
关键词
ITP; thrombopoietin; cyclic thrombocytopenia; antiplatelet antibody;
D O I
10.1002/ajh.1181
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:210 / 214
页数:5
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