Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice)

被引：176

作者：

Akihisa, T

Tokuda, H

Ukiya, M

Kiyota, A

Yasukawa, K

Sakamoto, N

Kimura, Y

Suzuki, T

Takayasu, J

Nishino, H

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem & Mol Biol, Kamigyo Ku, Kyoto 6020841, Japan

[3] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

来源：

CHEMISTRY & BIODIVERSITY | 2005年 / 2卷 / 10期

关键词：

D O I：

10.1002/cbdv.200590101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN- and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.

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页码：1305 / 1309

页数：5

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