Antimicrobial activity of the thiosulfinates isolated from oil-macerated garlic extract

被引：43

作者：

Yoshida, H

Katsuzaki, H

Ohta, R

Ishikawa, K

Fukuda, H

Fujino, T

Suzuki, A

机构：

[1] Nagoya Seiraku Co Ltd, Cent Inst, Biodev Div, Tempaku Ku, Aichi 4680065, Japan

[2] Mie Univ, Fac Bioresources, Tsu, Mie 5148507, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 03期

关键词：

antimicrobial effect; garlic; thiosulfinates; oil-macerated garlic extract; Allium sativum;

D O I：

10.1271/bbb.63.591

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three thilosulfinates were isolated from oil-macerated garlic extract, and their structures were identified as 2-propene-1-sulfinothioic acid S-(Z,E)-1-propenyl ester [Alls(O)sPm-(Z,E)], 2-propenesulfinothioic acid S-methyl ester [AllIS(O)SMe], and methanesulfinothioic acid S-(Z,E)-1-propenyl ester [MeS(O)SPn-(Z,E)]. This is the first report elf isolating these thiosulfinates from oil-macerated garlic extract. Antimicrobial activities of AllS(O)SPn(Z,E) and AllS(O)SMe against Gram-positive and negative bacteria and yeasts were compared with Z-propene-1-sulfinothioic acid S-2-propenyl ester [AllS(O)SAll, allicin] which is well-known as the major thiosulfinate in garlic. Antimicrobial activity of AllS(O)SMe and AllS(O)SPn-(Z,E) were comparable and inferior to that of allicin, respectively. This result suggested that the antimicrobial activity of 2-propene sulfinothioic acid S-alk(en)yl esters were affected by alk(en)yl groups. The order for antimicrobial activity was: allyl greater than or equal to methyl > propenyl.

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页码：591 / 594

页数：4

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