Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei

被引：90

作者：

Xiang, T

Xiong, QB

Ketut, AI

Tezuka, Y

Nagaoka, T

Wu, LJ

Kadota, S

机构：

[1] Shenyang Pharmaceut Univ, Dept Nat Med, Shenyang 110015, Peoples R China

[2] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama, Japan

来源：

PLANTA MEDICA | 2001年 / 67卷 / 04期

关键词：

Lonicera bournei Hemsl; Caprifoliaceae; quinic acid derivatives; caffeic acid derivatives; D-galactosamine (D-GalN); tumor necrosis factor alpha (TNF-alpha); hepatoprotective activity;

D O I：

10.1055/s-2001-14337

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicero bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)ltumor necrosis factor alpha (TNF-alpha) were studied, and the structure-activity relationships were also discussed.

引用

页码：322 / 325

页数：4

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