Donors of HNO

被引：77

作者：

Miranda, KM

Nagasawa, HT

Toscano, JP

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] DVA Med Ctr, Med Res Labs, Minneapolis, MN 55417 USA

[3] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 07期

关键词：

nitroxyl; nitric oxide; Angeli's salt; Piloty's acid; cyanamide; hydroxylarnines; sulfohydroxamic acids; acyl nitroso compounds; prodrugs; detection; characterization;

D O I：

10.2174/1568026054679290

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (LINO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.

引用

收藏

页码：649 / 664

页数：16

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